Abstract： Objective To evaluate outcomes after different treatment options including endoscopic stent placement,surgical bypass,and percutaneous gastrostomy for malignant gastric outlet obstruction(GOO).Methods Thirty-nine patients with GOO secondary to unresectable primary ormetastatic cancer were treated with endoscopic stent placement(group 1,n=13),surgical bypass(group 2,n=21),or percutaneous gastrostomy(group 3,n=5).QLQ-STO22 form was used to assess quality of life(QOL)at baseline,1 month,and 3 months following intervention.Results Overall median survival time was 68 days.Median survival time in group 1 and group 2 was 85 and 72 days respectively,longer than that in group 3(48 days,P<0.05).Fourteen patients(7 cases in group 1 and 7 cases in group 2) completed all three QOL surveys.All the patients in group 1 had significant improvement in dysphagia,dietary restrictions,dry mouth,and reflux(P<0.05).In group 2,dysphagia and dietary restrictions were significantly improved(P<0.05),while there were no significant improvements in dry mouth,reflux and pain(all P>0.05).Conclusion Although the prognosis of malignant GOO is poor,endoscopic stent placement and surgical bypass may improve QOL of pafients and therefore are reasonable alternatives for palliation.