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A meta-analysis of the safety of simultaneous versus staged resection for synchronous liver metastasis from colorectal cancer

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
Issue:
5
DOI:
10.3760/cma.j.issn.1671-0274.2010.05.011
Key Word:
结直肠肿瘤;肿瘤转移,肝;肝切除术;荟萃分析;Colorectal neoplasms;Neoplasm metastasis,liver;Hepatectomy;Metaanalysis

Abstract: Objective To evaluate the safety of simultaneous and staged resection for synchronous liver metastasis from colorectal cancer. Methods PubMed/Medline,ISI Web of Knowledge,Springer link,ebscohost,Elsevier Wiley Interscience,Google Scholar were searched for case-control studies concerning simultaneous versus staged resection of synchronous liver metastasis from colorectal cancer between January 1989 and March 2009.A meta-analysis sas performed to analyze the morbidity and periopemtive mortality. Results Seven case-control studies,with a total of 1 390 patients of liver metastasis from colorectal cancer undergone curative hepatic resection,were reviewed.There were 495 simultaneous and 895 staged resections.Periopemtive mortality was 1.1% in the staged resection group and 2.4% in the the simultaneous group,the difference was statistically significant[Peto OR 3.39,95% CI 1.29-8.93,P=0.01].No significant difference was found in morbidity between two groups [OR (random) 0.88,95% CI 0.51-1.51,P=0.64]. Conclusion Selective staged resection is safe for synchronous liver metastasis from colorectal cancer.

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