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Impact of width of hepatectomy margin on survival after simultaneous liver and colorectal resection for colorectal cancer liver metastasis

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
Issue:
4
DOI:
10.3760/cma.j.issn.1671-0274.2009.04.005
Key Word:
结直肠肿瘤;肝转移;肝切除术;切缘宽度;Colorectal neoplasms;Liver metastasis;Hepatectomy;Margin

Abstract: Objective To elucidate an adequate hepatectomy margin for simultaneous liver and colorectal resection in colorectal cancer liver metastasis. Methods Clinical data of 39 patients,undergone simultaneous liver and colorectal resection for colorectal cancer liver metastasis from August 1994 to December 2004, were analyzed retrospectively. Two groups were divided according to the width of hepatectomy margin:less than 1 cm in group A, and equal or more than 1 cm in group B. The data were analyzed and compared between the 2 groups using Kaplan-Meier survival analysis and Log-rank test. Results There were 14 patients in group A and 25 patients in group B. No significant differences in gender, age, primary tumor invasion, lymph node metastasis, the number, distribution and size of liver metastasis, duration and blood lose of surgery were found between two groups. The median survival time was 17 months in group A, and 37 months in group B, and the overall 5-year survival rate in group B was much better than that in group A (19.8% vs O, P<0.01). Conclusion Simultaneous liver and colorectal resection in colorectal cancer liver metastasis should be performed with a hepateetomy margin equal or more than 1 cm.

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