Up-regulation of HOXA13 in esophageal squamous cell carcinoma of stage II a and its effect on the prognosis
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1671-0274.2009.01.007
- Key Word:
- 食管鳞癌;基因,HOXA13;多因素分析;预后;Esophageal squamous cell carcinoma;Gene,HOXA13;Multivariate analysis;Prognosis
Abstract： Objective To investigate the expression of HOXA13 gene in stage-Ⅱa esophageal squamous cell carcinoma(ESCC), and to evaluate its relationship with clinicopathological characteristics and prognosis. Methods The expression of HOXAI3 was examined by immunohistochemistry(IHC) in specimens from 39 patients with ESCC of stage-Ⅱa, who underwent resection from 1995 to 2002. SPSS software was used to analyze the relationship between HOXA13 expression and clinicopathological characteristics and prognosis of patients. Results The expression of HOXA13 protein was detected in ESCC tissue, and the positive rate was 61.5%. The median survival time of patients without HOXA13 expression(>72 months) was significanfly longer than those with HOXA13 expression (24 months)(P=0.023). Multivariate analysis showed that HOXA13 expression was independent predictor of disease-free survival time of patients with ESCC. Conclusion The expression of HOXA13 can be detected in ESCC and is a negative independent predictor of disease-free survival, which implies that HOXA13 might play a role in ESSC, and may be used as a clinical tumor marker of ESCC.
- [1]陈龙奇.制订2009第7版食管癌TNM分期标准[J].2008,(1).
- [2]E B, Lewis.A gene complex controlling segmentation in Drosophila.[J].1978,276.
- [3]V, Raman,S A, Martensen,D, Reisman,etc.Compromised HOXA5 function can limit p53 expression in human breast tumours.[J].2000,405(6789).
- [4]D, Buffe,C, Rimbaut.alpha-Fetoprotein (alphaFP) as a marker for hepatoma and yolk sac tumors.[J].1979,67.
- [5]Andre Baruchel,Olivier Bernard,Henrik Hasle,etc.Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling[J].2006,103(9).
- [6]Golub, T.R.,Slonim, D.K..Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression ...[J].1999,286(5439).
- [7]S, von Kleist.The clinical value of the tumor markers CA 19/9 and carcinoembryonic antigen (CEA) in colorectal carcinomas: a critical comparison.[J].1900,1(1).
- [8]Kamangar F,Dores GM,Anderson WF.Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world.[J].2006,24(14).
- [9]J, Borrow,A M, Shearman,V P, Stanton,etc.The t(7; 11)(p15; p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.[J].1996,12.
- [10]Grier DG,Thompson A,Kwasniewska A,etc.The pathophysiology of HOX genes and their role in cancer.[J].2005,205(2).
- [11]张迺蘅主编.医学分子生物学[M].1999.
- [12]Ben Zion Vider,Amazia Zimber,Dania Hirsch,etc.Human Colorectal Carcinogenesis Is Associated with Deregulation of Homeobox Gene Expression[J].1997,232(3).