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Effect of total mesorectal excision and preoperative chemoradiotherapy on local recurrence in rectal cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1671-0274.2006.03.006
- Key Word:
- 直肠肿瘤;全直肠系膜切除;手术前放疗;手术前化疗;肿瘤复发,局部
Abstract： 目的研究全直肠系膜切除和术前治疗对直肠癌局部复发的影响.方法 2000年 1月至 2004年 8月间接受全直肠系膜切除手术的 161例直肠癌患者作为研究组;1996年 1月至 1999年 12月间接受直肠癌手术的 173例患者作为对照组.收集两组患者的临床病理和随访资料,比较其手术并发症、局部复发情况的差异.结果两组患者手术并发症发生率比较( P >0.05),差异无统计学意义.研究组肿瘤局部复发率为 2.5%,低于对照组的 8.0%(χ 2=5.144;P=0.023).研究组中 57例接受术前治疗,肿瘤局部复发率为 1.8%;而没有接受术前治疗患者的肿瘤局部复发率为 3.0% (χ 2=1.781, P=0.182);差异无统计学意义.将患者性别、年龄、手术方式、全直肠系膜切除与否、接受术前治疗与否、肿瘤大体类型、分化程度、分期、脉管癌栓、辅助化疗等因素作为协变量,以肿瘤局部复发作为因变量行 Logistic回归分析.结果显示全直肠系膜切除和脉管癌栓是影响直肠癌局部复发的主要因素.结论全直肠系膜切除和脉管癌栓有无是影响直肠癌局部复发的主要因素.
- [1]R J, Heald.Total mesorectal excision is optimal surgery for rectal cancer: a Scandinavian consensus.[J].1995,82(10).
- [2]Lygidakis NJ,Safioleas MC,Stamatakos M,etc.Local recurrence following curative low anterior resection for rectal carcinoma.[J].2005,52(61).
- [3]Darzi AW,Ridgway PF.The role of total mesorectal excision in the management of rectal cancer.[J].2003,10(3).
- [4]Ohizumi Y,Ishikawa K,Makuuchi H,etc.Preoperative radio/chemo-radiotherapy in combination with intraoperative radiotherapy for T3-4Nx rectal cancer.[J].2004,30(7).
- [5]Young Taik, Oh,Myeong Jin, Kim,Joon Seok, Lim,etc.Assessment of the prognostic factors for a local recurrence of rectal cancer: the utility of preoperative MR imaging.[J].1900,6.
- [6]Cianchi F,Palomba A,Boddi V,etc.Tumor angiogenesis in lymph node-negative rectal cancer: correlation with clinicopathological parameters and prognosis.[J].2002,9(1).
- [7]Nagtegaal ID,Van De Velde CJ,Klein Kranenbarg E,etc.Clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy.[J].2004,22(19).
- [8]R J, Heald,B J, Moran,G, Brown,etc.Optimal total mesorectal excision for rectal cancer is by dissection in front of Denonvilliers' fascia.[J].2004,91(1).