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Imatinib mesylate STI571 therapy for five patients with advanced gastrointestinal stromal tumors
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1671-0274.2005.02.009
- Key Word:
- 伊马替尼;胃肠道间质瘤;跨膜受体酪氨酸激酶基因
Abstract： 目的探讨伊马替尼对晚期胃肠道间质瘤 (gastrointestinal stromal tumour, GISTs)的治疗作用.方法 回顾性分析经伊马替尼治疗的 5例晚期胃肠道间质瘤患者的临床资料.结果 5例患者的肿瘤组织(其中有 4例曾接受1～ 3次手术)经免疫组织化学法证实表达 c-kit基因,因肿瘤严重浸润或广泛转移已无手术指征,对射频和全身化疗无效.经伊马替尼 (400 mg/d)1～ 6个月治疗后肿瘤明显缩小,病情稳定;且未发生明显的药物不良反应.结论伊马替尼可有效治疗晚期不可切除或转移的 GISTs.跨膜受体酪氨酸激酶 (Kit)信号传导通路的抑制剂有别于传统的化疗,是治疗 GISTs的一种非常有潜力的治疗方案.
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