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Preoperative chemoradiotherapy as neoadjuvant therapy for 35 patients with locally advanced lower rectal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1671-0274.2005.02.008
- Key Word:
- 直肠肿瘤;化疗,术前;放疗,术前
Abstract： 目的探讨新辅助治疗对低位局部进展期直肠癌的临床治疗价值.方法对 35例低位局部进展期直肠癌患者,采用新辅助治疗方案.常规分割放疗,放疗总剂量 DT:46 Gy,每次 2 Gy,每周 5次.全身化疗 2个疗程,每次予以奥沙利铂 130 mg/m2,第 1天静脉点滴;甲酰四氢叶酸钙(CF) 200 mg/m2,第 1～ 3天静脉点滴;氟尿嘧啶(5-FU) 500 mg/m2,第 1～ 3天静脉点滴.治疗结束后 4～ 6周进行手术.结果 经新辅助治疗后,病理完全缓解 7例,肿瘤平均缩小 34.4%, 65.7%的病例 T分期下降,淋巴结阴转率为 55.6%.根治切除 34例,其中腹会阴联合切除 18例,保肛手术 16例,保肛率为 45.7%.姑息性 Hartmann术 1例.随访至今,肝转移 2例,根治切除术后无 1例局部复发.保肛患者肛门功能良好.结论对低位局部进展期直肠癌患者采用新辅助治疗,可使肿瘤分期降低,提高手术切除率和保肛率.
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