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Study on the relation of the cellular proliferative activity to lymphatic,vascular invasions and prognosis in gastric carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1671-0274.2004.06.007
- Key Word:
- 胃肿瘤;增殖活性;肿瘤浸润;肿瘤转移;流式细胞术;预后
Abstract： 目的探讨溴化脱氧脲嘧啶核苷( BrdUrd) /DNA双参数流式细胞术检测胃癌细胞增殖的临床价值,研究胃癌细胞 BrdUrd标记指数( LI)、 G2/M期细胞比率 (G2/MPF)和 DNA含量与胃癌临床病理学及预后的关系.方法用 BrdUrd/DNA双参数流式细胞术检测 60例胃癌新鲜标本.结果浆膜受侵者较未受侵者 BrdUrd LI明显增高( P< 0.01),两者 5年生存率比较,差异有显著性意义( P< 0.01).淋巴管浸润阳性者和淋巴结转移阳性者均较阴性者 BrdUrd LI和 G2/MPF明显增高( P< 0.01),其 5年生存率与阴性者比较,差异也有显著性意义( P< 0.01).异倍体癌淋巴结阳性者明显增多( P< 0.05).异倍体癌与二倍体癌比较 5年生存率,差异有显著性意义( P< 0.05).腹膜播散阳性者 5年生存率较阴性者明显降低( P< 0.01);静脉浸润阳性较阴性者 G2/MPF明显增高( P< 0.01).结论胃癌细胞 BrdUrd LI、 G2/MPF和 DNA含量与胃癌浸润深度、淋巴管浸润、淋巴结转移、腹膜播散、静脉浸润及预后有关.
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