Abstract： Objective To study the short- and long-term clinical results of 48 chronic duodenal ulcer patients treated with pylorus-preserved mucosal antrectomy plus high selective vagotomy(PPMA + HSV) . Methods Clinical follow-up results of the patients from 3～6 months and 8～12 years were summarized. Results Forty-five (93.8%) patients of 3～6 months follow-up and 20/21 (95.3%) patients of 8～12 years follow-up after operation achieved Visick grades Ⅰ～Ⅱ. No patient died. Gastric acid secretion and infection rate of helicobacter pylori in antral mucosa were significantly reduced after operation. No significant difference was found in bile acids of gastric juice and in the level of serum gastrin after operation. No ulcer recurrence was found by barium meal and endoscopy. Conclusion PPMA + HSV is a better operative treatment for duodenal ulcer, which can decrease the acid secretion, the rate of ulcer recurrence and postoperative complications effectively and lastingly.