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Epigenetics mechamisms for relationships between intrauterine growth environment and adult glucose metabolism

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Author:
No author available
Journal Title:
Chinese Journal of Diabetes
Issue:
9
DOI:
10.3969/j.issn.1006-6187.2012.09.023
Key Word:
不良宫内发育环境;糖代谢异常;表观遗传学

Abstract: 糖尿病的发生是遗传和环境因素共同作用的结果.近年来,人们开始关注生命早期发育状况对成年期疾病的影响.越来越多证据显示,宫内不良发育环境(IUGR)导致成年期糖代谢异常可能是通过表观遗传机制发挥作用的,如通过基因的甲基化修饰、组蛋白密码影响基因的表达,此遗传倾向最终导致后代临床表型变化.不良宫内发育环境(IUGR)模型鼠研究显示,在胰岛、肝脏和骨骼肌组织中与糖代谢相关的基因均发生了表观遗传修饰改变,导致相应组织基因表达异常,增加了糖代谢异常发生风险.

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