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Thrice daily regimen of biphasic insulin aspart (BIAsp 50-50-30) versus twice daily regimen of biphasic insulin aspart 30 (BIAsp 30-30), both in combination with metformin- Comparison of their efficacy and safety in T2DM patients
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2012.09.015
- Key Word:
- 糖尿病,2型;预混人胰岛素;双时相门冬胰岛素50;双时相门冬胰岛素30
Abstract： 目的 比较每日3次注射双时相门冬胰岛素(BIAsp 50-50-30)与每日2次注射双时相门冬胰岛素(BIAsp 30-30)均联合二甲双胍治疗T2DM患者的疗效和安全性. 方法 对144例预混人胰岛素控制不佳的T2DM患者进行1项为期16周,多中心、随机、开放、平行分组的治疗达标试验.主要疗效指标为HbA1c的变化,其他指标包括8点血糖谱、HbA1c＜7.0％的受试者百分比、餐后血糖增幅、不良事件和低血糖事件等. 结果 治疗16周后,BIAsp 50-50-30组HbA1c的控制优于BIAsp 30-30组[HbA1c分别下降(1.81±1.09)％和(1.48±1.14)％,差值为-0.27％,95％CI(-0.43,-0.12)].BIAsp 50-50-30组HbA1c＜7％的受试者比例更高,且午餐后2h及晚餐前血糖水平显著低于BIAsp 30-30组(P＜0.001).两组平均餐后血糖增幅的变化相似,低血糖事件发生频率和体重增加无统计学差异.结论 注射BIAsp 50-50-30每日3次对HbA1c的控制优于注射BIAsp 30-30每日2次,且不增加低血糖风险及体重.
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