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Effect of combined therapy with alfacacidol and telmisartan on diabetic nephropathy in early stage
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2012.09.012
- Key Word:
- 糖尿病肾病;阿法骨化醇;替米沙坦;治疗结果
Abstract： 目的 观察阿法骨化醇联合替米沙坦治疗早期DN疗效. 方法 60例门诊及住院符合入选条件的DN患者随机分为单用阿法骨化醇组(0.25 μg/d)、替米沙坦组(20～40mg/d)、阿法骨化醇(0.25μg/d)联合替米沙坦组(20～40mg/d)进行治疗,每组20例,血压均控制在125/75mmHg以下,疗程12周,治疗前后观察3组患者FBG、HbA1c、血压、24 h UAlb、BUN、肌肝(Cr)、血钙、血钾等水平.结果 3组治疗后24 h UAlb均下降(P＜0.05),联合用药组下降更明显(P＜0.01).其他指标变化差异无统计学意义(P＞0.05).60例患者治疗期间无明显不良反应. 结论 阿法骨化醇和替米沙坦均能降低DN患者的尿蛋白,联合应用疗效更佳.
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