You Position: Home > Paper
Relationship of serum 8-OHdG and VEGF with diabetic nephropathy in diabetics
( views:342, downloads:146 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2012.09.010
- Key Word:
- 糖尿病肾病;糖尿病,2型;8-OHdG;VEGF
Abstract： 目的 探讨DNA氧化损伤标志物血清8-羟基脱氧鸟苷酸(8-OHdG)和血管内皮生长因子(VEGF)与糖尿病肾病(DN)的关系. 方法 随机检测71例DN患者,73例糖尿病患者及健康对照者47名,采用酶联免疫吸附实验(ELISA)法测定其血清8-OHdG、VEGF水平24 h微量白蛋白,并与47名健康对照者进行比较. 结果 8-OHdG和VEGF水平DN组显著高于糖尿病组(P＜0.01),糖尿病组高于正常对照组(P＜0.05).大量蛋白尿组明显高于微量蛋白尿组(P＜0.05).HbA1c＞10％组明显高于糖化血红蛋白＜9％组(P＜0.05). 结论 DN与血清8-OHdG、VEGF有关,氧化应激和VEGF参与DN发生发展过程.
- [1]郭翼华,项嘉亮,王小朝.8-羟基脱氧鸟苷酸检测在预防糖尿病并发症发生的临床价值[J].2008,(5).
- [2]鲁燕,陆轶群,李红霞.2型糖尿病患者血清8-羟基脱氧鸟苷酸水平与大血管病变的相关性[J].2007,27(5).
- [3]高瑞霄,姚朱华,邵红霞.尿8-OHdG与糖尿病性动脉粥样硬化相关性的研究进展[J].2009,(9).
- [4]Shin JY,Chung CH,Shin YG,etc.Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: the role of reducing oxidative stress in its protective property.[J].2009,83(2).
- [5]Liu T,Gan Y,Liu D,etc.Imbalance of glomerular VEGF-NO axis in diabetic rats: prevention by chronic therapy with propyl gallate.[J].2011,24(4).
- [6]朱禧星.现代糖尿病学[M].2000.
- [7]Kim YS,Chang YS,Kim HW,etc.Long-term blockade of vascular endothelial growth factor receptor-2 aggravates the diabetic renal dysfunction associated with inactivation of the Akt/eNOS-NO axis.[J].2011,26(4).
- [8]Iimura O,Ishibashi K,Kusano E,etc.The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients.[J].2011,15(3).
- [9]Sato T,Tomohiro T,Kimura K,etc.Hypertension aggravates glomerular dysfunction with oxidative stress in a rat model of diabetic nephropathy.[J].2007,80(15).
- [10]Monnier L,Mas E,Ginet C,etc.Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes.[J].2006,295(14).
- [11]Fukagawa M,Hamada Y,Shinohara M,etc.Oxidative and nitrosative stress and progression of diabetic nephropathy in type 2 diabetes.[J].2010,31(4).