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Influence of pioglitazone and metformin on serum adiponectin level in patients with type 2 diabetes mellitus
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2012.09.008
- Key Word:
- 糖尿病,2型;脂联素;吡格列酮;二甲双胍;肥胖
Abstract： 目的 探讨吡格列酮和二甲双胍治疗对肥胖T2DM患者血清APN的不同影响. 方法将48例新诊断的肥胖T2DM患者随机分两组,分别给予二甲双胍(M组)和二甲双胍联合吡格列酮(MP 组)治疗12周；于治疗前后测定受试者空腹血清APN、FPG、HbA1c、血脂、FIns,计算BMI、胰岛素抵抗指数(HOMA-IR). 结果 与治疗前相比,MP组APN水平明显升高(P=0.0005),MP组FPG、HbA1c、HOMA-IR、BMI、FIns明显降低(P＜0.05)；与治疗前相比,M组APN水平无明显改变(P=0.487),BMI、FPG、HbA1c、HOMA-IR、FIns、LDL-C明显降低(P＜0.05). 结论 吡格列酮能有效增加肥胖T2DM患者血清APN水平.
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