Back to the preclinical medicine:Evaluation of the safety of insulin detemir

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LU Jun-min()
Journal Title:
Chinese Journal of Diabetes
Volume 20, Issue 08, 2012
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  • [1]Home p,Kurtzhals P.Insulin detemir:from concept to clinical experience.Expert Opin Pharmacother,2006,7:325-343.
  • [2]Raskin P.Efficacy and safety of insulin determir.Endocrinol Metab Clin North Am,2007,36(Suppl):21-32.
  • [3]Le Floch JP.Critical appraisal of the safety and efficacy of insulin detemir in glycemic control and cardiovascular risk management in diabetics.Diabetes Metab Syndr Obes,2010,3:197-213.
  • [4]Blonde L,Merilainen M,Karwe al.Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue:an assessment of two different fasting plasma glucose targets-the TITRATETM study.Diabetes Obesity and Metabolism,2009,11:623-631.
  • [5]Philis-Tsimikas A.An update on the use of insulin detemir,with a focus on type 2 diabetes(drug evaluation update).Expert Opin Pharmacother,2008,9:2181-2195.
  • [6]John M.Basal insulin analogues—a review of recent data on efficacy and safety.J Assoc Physicians India,2011,59(Suppl):25-28.
  • [7]Raslova K.An update on the treatment of type 1 and type 2 diabetes mellitus:focus on insulin detemir,a long-acting human insulin analog.Vasc Health Risk Manag,2010,1:399-410.
  • [8]Heise T,Pieher TR.Towards peakless,reproducible and longacting insulins.An assessment of the basal analogues based on isoglycaemic clamp studies.Diabetes Obes Metab,2007,9:648-659.
  • [9]Philis-Tsimikas A,Charpentier G,Clauson P,et al.Comparison of once-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes.Clin Ther,2006,28:1569-1581.
  • [10]Domhorst A,Lüddeke HJ,Koenen C,et al.Transferring to insulin detemir from NPH insulin or insulin glargine in type 2 diabetes patients on basal-only therapy with oral antidiabetic drugs improves glycaemic control and reduces weight gain and risk of hypoglycaemia:14-week follow-up data from PREDICTIVE.Diabetes Obes Metab,2008,10:75-81.
  • [11]Swinnen SG,Simon AC,Holleman F,et al.Insulin detemir versus insulin glargine for type 2 diabetes mellitus.Cochrane Database Syst Rev,2011.
  • [12]Monami M,Marchionni N,Mannucci E.Long-acting insulin analogues versus NPH human insulin in type 2 diabetes:a metaanalysis.Diabetes Res Clin Pract,2008,81:184-189.
  • [13]Raskin P,Gylvin T,Weng W,et al.Comparison of insulin detemir and insulin glargine using a basal-bolus regimen in a randomized,controlled clinical study in patients with type 2 diabetes.Diabetes Metab Res Rev,2009,25:542-548.
  • [14]Fajardo MC,Hernandez HC,Rivas FM.Less weight gain and hypoglycaemia with once-daily insulin detemir than NPH insulin in intensification of insulin therapy in overweight Type 2diabetes patients:the PREDICTIVE BMI clinical trial.Diabet Med,2008,25:916-923.
  • [15]Dornhorst A,Luddeke HJ,Sreenan S,et al.Insulin detemir improves glycaemic control without weight gain in insulin-naive patients with type 2 diabetes:subgroup analysis from the PREDICTIVE study.Int J Clin Pract,2008,62:659-665.
  • [16]Vora J,Orozco-beltran D,Karnieli al.Study of Once-Daily Levemir(SOLVE):Weight changes associated with the initiation of once-daily insulin deternir in patients with T2DM.Internation diabetes federation(IDF)poster disccusion,2011-08-07(D-0829).
  • [17]Bush MA.Intensive diabetes therapy and body weight:focus on insulin deternir.Endocrinology & Metabolism Clinics of North America,2007,36(Suppl):33-44.
  • [18]Gupta GK,Gupta VK,Shukla P,et al.Investigations on cellular interaction of polyelectrolyte based nano-walled reservoir using MCF-7 cell lines:a novel chemotherapeutic approach.J Pharm Pharmacol,2009,61:1601-1607.
  • [19]Smith U,Gale EA.Does diabetes therapy influence the risk of cancer? Diabetologia,2009,521:699-708.
  • [20]Danne T,Ltlpke K,Walte K,et al.Insulin detemir is characterized by a consistent pharmacokinefic profile across agegroups in children,adolescents,and adults with type 1 diabetes.Diabetes Care,2003,26:3087-3092.
  • [21]Kurtoglu S,Atabek ME,Dizdarer C,et al.Insulin detemir improves glycemic control and reduces hypoglycemia in children with type 1 diabetes:findings from the Turkish cohort of the PREDICTIVE observational study.Pediatr Diabetes,2009,10:401-407.
  • [22]Mathiesen ER,Hod M,Ivanisevic M,et al.Maternal efficacy and safety outcomes in a randomized controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes mellitus.Diabetes Care,2012.35:1246-1248.
  • [23]Kerlan V,Vergès B,Tawil C,et al.Insulin initiation in elderly patients with type 2 diabetes in France:a subpopulation of the LIGHT study.Current Medical Research & Opinion,2012,28:1-9.
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