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Correlation between plasma AHSG level and lower extremity atherosclerosis in type 2 diabetes complicated with renal insufficiency
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2012.08.005
- Key Word:
- 糖尿病;α2-HS-糖蛋白/AHSG;动脉粥样硬化;肾小球滤过率
Abstract： 目的 探讨不同肾功能状态下T2DM患者血浆α2-HS-糖蛋白(AHSG)水平与下肢动脉粥样硬化(AS)程度的关系及其相关因素分析.方法 T2DM患者226例,按肾小球滤过率估计值(eGFR)分为肾功能正常组(A组),肾功能轻度下降组(B组),肾功能中重度下降组(C组).所有患者采用彩色多普勒超声仪进行双下肢AS检查,并通过ELISA法进行血浆AHSG水平检测,分析不同肾功能状态下二者的关系.结果(1)C组下肢AS发生率和评分高于A、B组,血浆AHSG水平低于A、B组,差异均有统计学意义(P＜0.01).(2)A、B组血浆AHSG水平与下肢AS评分无相关性(P＞0.05),C组中二者呈正相关(r=0.592,P＜0.01).(3)逐步回归分析显示C组HbA1c、TC、TG、eGFR、AHSG 是下肢动脉硬化程度的影响因素(P＜0.05或P＜0.01).结论 在肾功能中、重度下降时血浆AHSG 水平是衡量T2DM下肢AS严重性的指标之一.
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