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Relationship of fasting plasma glucose with β-cell function and insulin sensitivity
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 5
- DOI:
- 10.3969/j.issn.1006-6187.2012.05.001
- Key Word:
- 糖尿病,2型;β细胞功能;胰岛素敏感性;空腹血糖
Abstract： 目的 评估FPG与胰岛β细胞功能及IS之间的关系. 方法 采用多阶段分层整群随机抽样方法对江苏省1277例人群进行研究,根据OGTT分为NGT、IFG、IGT、IGR、T2DM组.IS用ISI及1/HOMA-IR评价;β细胞功能用经IS校正的处置指数DI(包括DI0、DI30、DI120)评估. 结果 同NGT组ISI、DI0、DI30、DI120相比,IGT组分别下降25.2％、17.1％、37.2％、12.5％;IFG组分别下降23.5％、65.4％、37.6％、37.1％;IGR组分别下降42.7％、70.1％、56.5％、38.1％;T2DM组分别下降44.7％、83.4％、76.0％、66.0％. 结论 在正常糖耐量阶段,随着FPG升高,IS和胰岛素分泌有下降趋势,两者共同促进FPG的升高.
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