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Changes of the level of serum apelin and its relative factors in patients with polycystic ovarian syndrome
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-6187.2012.02.002
- Key Word:
- 多囊卵巢综合征;Apelin;肥胖症;胰岛素抵抗
Abstract： 目的 测定多囊卵巢综合征( PCOS)患者的血清Apelin水平,并探讨其与FIns、HOMAIR、BMI等的相关性. 方法 69例PCOS患者和31名对照,按BMI≥25 kg/m2或＜25 kg/m2又各自分为超重/肥胖与正常体重亚组,采用放免法检测空腹血清Apelin水平,同时检测FPG、FIns、性激素水平,计算BMI、WHR及HOMA-IR. 结果 (1)PCOS组FIns、HOMA-IR和血清Apelin水平明显高于对照组[FIns:(45.12±55.59)vs(7.31±5.72) mU/L;HDMA-IR:(10.19±12.63) vs (1.62±1.23);Apelin:(229.37±19.38) vs (218.58±15.95) ng/L,P均＜0.01].按BMI分为超重/肥胖和正常体重亚组后,PCOS两亚组的FIns和HOMA-IR均高于相应对照亚组,PCOS组的超重/肥胖亚组Apelin水平显著高于相应对照亚组.(2)空腹血清Apelin水平与BMI、腰围、FIns和HOMA-IR呈正相关(r值分别为0.705、0.558、0.435、0.429,P＜0.01).(3)多元逐步回归分析发现,BMI是影响血清Apelin水平的独立相关因素. 结论 血清Apelin水平变化与BMI、胰岛素抵抗有关,并可能在PCOS的发生发展中起一定的作用.
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