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Study of relationship between serum alanine aminotransferase level and the different states of glucose metabolism
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-6187.2012.02.001
- Key Word:
- 丙氨酸转氨酶;糖调节异常;糖尿病;胰岛素抵抗
Abstract： 目的 探讨糖尿病高危人群在不同糖代谢状态下血清丙氨酸转氨酶( ALT)的变化及其相关因素. 方法 对871例门诊行糖耐量筛查患者,按照糖代谢状况分为新诊断的T2DM组285例,糖调节受损(IGR)组407例,正常糖耐量(NGT)组179例,比较各组血清ALT的变化,分析ALT的相关因素及其与T2DM患病率的关系. 结果 (1)在校正了年龄、BMI、腰围、TG和HDL-C的影响后,血清ALT水平T2DM组和IGR组均高于NGT组(P=0.001,P=0.032).(2)血清ALT水平与BMI、腰围及HOMA-IR关系最为密切(r分别是0.303、0.316、0.322).(3)在校正了性别、年龄、BMI和腰围的影响后,随着血清ALT水平的增加,T2DM患病率明显增加,其中第四分位组患T2DM的危险性是第一分位组的2.16倍(95％CI 1.41～3.32).在进一步校正了血脂和HOMA-IR的影响后,这种关联仍存在,但有所减弱. 结论 血清ALT水平的升高与T2DM的发生有关联,且这种相关可能独立于肥胖、血脂、胰岛素敏感性和分泌功能而存在.
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