You Position: Home > Paper
A clinical use of insulin detemir in the elderly with type 2 diabetes
( views:304, downloads:233 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2012.01.013
- Key Word:
- 老年;糖尿病,2型;地特胰岛素;甘精胰岛素;中性鱼精蛋白锌胰岛素
Abstract： 目的 比较口服降糖药(OAD)血糖控制不佳的老年T2DM患者,加用地特胰岛素、甘精胰岛素或中性鱼精蛋白锌胰岛素(NPH)治疗的有效性和安全性.方法 114例OAD血糖控制不佳的老年T2DM患者随机分为三组,分别加用地特胰岛素(Det组)、甘精胰岛素(Gla组)或NPH(NPH组),治疗24周.结果 治疗24周后,三组HbA1c、FBG和2hBG均较基线下降,但三组间差异无统计学意义(P＞0.05)；胰岛素用量在三组间无统计学差异(P＞0.05)；Det组体重增加较Gla组和NPH组更少(P＜0.05或P＜0.01)；Det组及Gla组低血糖发生率为0.9％,较NPH组的5.3％更低(P＜0.01).结论 OAD血糖控制不佳的老年T2DM患者,加用地特胰岛素、甘精胰岛素或NPH均可有效控制血糖,但地特胰岛素在减少体重增加及低血糖发生上更有优势.
- [1]沈洁.地特胰岛素减少体重增加的可能机制与临床应用[J].2010,(3).
- [2]Eliasson B,Zethelius B,Eeg-Olofsson K,etc.Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in 13,087 patients.[J].2009,52(1).
- [3]Yang W,Lu J,Weng J,etc.Prevalence of diabetes among men and women in China.[J].2010,362(12).
- [4]Kolendorf K,Garber AJ,Clauson P,etc.Lower risk of hypoglycemia with insulin detemir than with neutral protamine hagedorn insulin in older persons with type 2 diabetes: a pooled analysis of phase III trials.[J].2007,55(11).