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Association of the single nucleotide polymorphism (SNP) of the PRKAA2 with T2DM, adiponectin and resistin in Gansu, China
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 10
- DOI:
- 10.3969/j.issn.1006-6187.2011.10.004
- Key Word:
- 糖尿病,2型;PRKAA2基因;单核苷酸多态性;脂联素;抵抗素
Abstract： 目的 探讨甘肃地区PRKAA2基因rs2746342 (G/T)单核苷酸多态性与T2DM及血清脂联素(APN)、抵抗素(Resistin)的关系.方法甘肃地区T2DM患者163例和正常对照组86名,两组年龄、性别匹配,采用聚合酶链反应/DNA限制性片段长度多态性(PCR/RFLP)、酶联免疫分析(ELISA)检测其基因多态性、空腹C肽(FC-P)、APN、Resistin,同时测身高、体重、血压、BMI、空腹血糖、血脂等.结果(1)T2DM组与正常对照组的基因型和等位基因频度分布存在显著差异(P＜0.05)；(2) T2DM组各基因型T/T、G/T、G/G中Resistin、TG、TC、LDL-C、FC-P依次降低,APN、HDL-C依次增高(P＜0.05)；(3)APN水平在糖尿病超重组低于糖尿病正常体重组和对照组,Resistin水平在糖尿病超重组高于糖尿病正常体重组和对照组(P＜0.05)；(4)相关分析表明APN水平与BMI、血压负相关,与C-肽正相关(P＜0.05),Resistin水平与BMI、血压正相关,与C-肽负相关(P＜0.05)；(5) T2DM超重组较T2DM正常体重组和正常对照组TG、LDL-C水平升高(P＜0.05),HDL-C水平降低(P＜0.05).结论甘肃地区PRKAA2基因rs2746342 (G/T)单核苷酸基因多态性可能与T2DM及胰岛素抵抗、血清APN、Re-sistin水平关联.
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