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Relationship between ghrelin gene Leu72Met polymorphism and type 2 diabetes mellitus

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Author:
No author available
Journal Title:
Chinese Journal of Diabetes
Issue:
10
DOI:
10.3969/j.issn.1006-6187.2011.10.003
Key Word:
Ghrelin;糖尿病,2型;基因多态性

Abstract: 目的 探讨Ghrelin基因Leu72Met多态性与T2DM之间的相关性.方法采集316例T2DM患者和203名健康对照组(NGT组)人群的一般临床资料,利用PCR-RFLP进行Ghrelin基因Leu72Met的多态性分析.结果T2DM组的Leu72Met基因型分布及等位基因频率与NGT组相比差异无统计学意义.NGT Met72携带者血清LDL-C水平较同组Leu72纯合子个体增高(P<0.05).结论Ghrelin基因Leu72Met分布与等位基因频率在T2DM和健康人群无明显差异,该基因多态性在健康人群可能与血清LDL-C水平相关.

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