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The association of SUMO4 gene 163 A/G polymorphism with type 2 diabetic nephropathy
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 10
- DOI:
- 10.3969/j.issn.1006-6187.2011.10.002
- Key Word:
- 糖尿病,2型;糖尿病肾病;多态性,基因;小泛素样修饰蛋白4
Abstract： 目的 探讨小泛素样修饰蛋白4 (SUMO4)基因163 A/G多态性与2型糖尿病肾病(DN)的相关性.方法运用聚合酶链反应一限制性片段长度多态性(PCR-RFLP)方法对232例T2DM患者,其中正常白蛋白尿103例(N-UAlb组)、微量白蛋白尿65例(M-UAlb组)、大量白蛋白尿64例(L-UAlb组),以及102名健康对照(NC组)的SUMO4基因163 A/G多态性进行检测,并比较各组间基因型频率、等位基因频率及相关临床资料.结果 NC组和T2DM组基因型和等位基因频率无统计学差异；M-UAlb和L-UAlb组的GA基因型频率高于N-UAlb组(P＜0.05).结论在昆明地区汉族人群中,SUMO4基因GA基因型可能是DN发生的危险因素.
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