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The sCD40L level in healthy first-degree relatives of type 2 diabetes and its related factors
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2011.08.014
- Key Word:
- 可溶性CD40配体;糖尿病,2型;一级亲属
Abstract： 目的 本文旨在观察2型糖尿病(T2DM)患者正常糖耐量一级亲属(FDR)血清可溶性CD40配体(sCD40L)水平的变化,并分析相关影响因素.方法;在41个T2DM家系中收集糖耐量正常的FDR26名,同时设T2DM患者24例(T2DM组),健康者21名作为对照(Con组).采用ELISA法测定血清sCD40L水平.结果:NGT-FDR组的sCD40L水平较对照组升高(1.88±0.47 vs 1.63±0.58,P=0.182),T2DM组sCD40L水平显著升高(2.14±0.75,P=0.043 vs Con组).sCD40L水平与空腹血糖呈正相关(r=0.325,P=0.006).结论 T2DM患者血清sCD40L明显高于糖耐量正常者;T2DM患者正常糖耐量一级亲属血清sCD40L水平已呈升高趋势;sCD40L水平与空腹血糖水平呈正相关.我们推测sCD40L升高在T2DM自然病程中可能发挥一定作用.
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