You Position: Home > Paper
The changes in the cortisol secretion and regulation in the patients with type 2 diabetes
( views:238, downloads:152 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2011.08.013
- Key Word:
- 糖尿病,2型;皮质醇;HPA轴
Abstract： 目的 探讨2型糖尿病(T2DM)患者皮质醇分泌和下丘脑-垂体-肾上腺(HPA)轴活性的改变.方法 选取2型糖尿病患者114例(T2DM组)和17例单纯向心性肥胖患者、正常对照80名(NC组),T2DM组再按腰围分为肥胖组和非肥胖组,比较4组皮质醇分泌水平和HPA轴活性.结果:4组患者皮质醇基础水平无差异;用地塞米松后T2DM+OB组女性患者皮质醇被抑制程度较NC组少(P<0.05);与T2DM+OB组、NC组比较,T2DM组患者肾上腺被兴奋程度最高,尤其在男性(P<0.05).结论 不同体脂分布、不同性别T2DM患者存在HPA轴活性的差异.
- [1]刘建,王运林,廖文慧,等.男性老年人胰岛素抵抗指数与胰岛素分泌曲线的对照分析[J].2007,(6).
- [2]Pagotto U,Gambineri A,Vicennati V,etc.Sex-dependent role of glucocorticoids and androgens in the pathophysiology of human obesity.[J].2008,32(12).
- [3]Epaminonda P,Ambrosi B,Morelli V,etc.Cortisol secretion in patients with type 2 diabetes: relationship with chronic complications.[J].2007,30(1).
- [4]Ziolkowska A,Nussdorfer GG,Belloni AS,etc.Leptin and the regulation of the hypothalamic-pituitary-adrenal axis.[J].2007,263(0).
- [5]Reynolds RM.Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes.[J].2010,122(1).