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The association between the MALDI-TOF-MS detected RBP4 gene polymorphism and type 2 Diabetes mellitus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 7
- DOI:
- 10.3969/j.issn.1006-6187.2011.07.004
- Key Word:
- 糖尿病,2型;视黄醇结合蛋白4;基因多态性
Abstract： 目的 探讨重庆地区视黄醇结合蛋白4(RBP4)基因多态性与2型糖尿病(T2DM)及临床表型的关联性.方法 运用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS) 技术检测中国重庆地区335例无亲缘关系的人群(T2DM患者184例,正常对照151名)中RBP4基因rs17484721和rs3758539多态性.结果 RBP4基因rs17484721和rs3758539位点多态性在糖尿病和对照组之间差异均无统计学意义(P>0.05).糖尿病组rs17484721AA基因型携带者的HOMA2IR值明显高于其他基因型(ANCOVA=5.181,P<0.05),rs3758539GA+AA基因型携带者的空腹血糖值明显高于GG基因型(ANCOVA=6.246,P<0.05).结论 中国汉族人群中RBP4基因多态性可能与T2DM相关.
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