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Meta-analysis of the association of Pro12Ala polymorphism of PPARγ gene with type 2 diabetes in Chinese Han population

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF DIABETES

Issue:: 7

DOI:: 10.3969/j.issn.1006-6187.2011.07.002

Key Word:: 过氧化物酶体增殖物激活受体;Pro12Ala;糖尿病,2型;Meta分析

Abstract：目的评价我国汉族人群过氧化物酶体增殖物激活受体γ( PPARγ)基因多态性Pro12Ala与2型糖尿病的相关性.方法以"PPARγ","pparg","Pro12Ala","type 2 diabetes","Chinese","过氧化物酶增殖剂激活受体","2型糖尿病"为检索词,全面检索2型糖尿病与Pro12Ala相关的文献,用Stata 11.0 进行Meta 分析,对研究数据的OR值进行合并,并评价分析结果的可靠性和稳定性.结果 (1)检索到22篇,其中17篇符合纳入标准,包含了3927例2型糖尿患者和3364名正常对照,共7921名.纳入研究人群同质性较好,无显著发表偏倚.(2)次要等位基因Ala12在正常人和2型糖尿病患者中的频率分别为4.8%与4.6%.在显性和加性遗传模式下,次要等位基因携带者相对于未携带者的OR值分别为0.95(95% CI:0.80,1.12)和0.93(95% CI:0.79,1.09).结论我国汉族人群 PPARγ2基因多态性Pro12Ala与T2DM无相关性.

Reference

[1]孙福红,魏水易,许自明,等.随机对照试验Meta分析的质量评价[J].2002,(1).
[2]李云春,钟慧军,霍正浩,等.过氧化物酶增殖体激活受体-γ2基因多态性与2型糖尿病遗传易感性的相关性研究[J].2006,(3).
[3]傅健,池上博司,吕远栋,等.过氧化物酶体增殖物激活受体γ2基因Pro12→Ala可能是我国汉族人2型糖尿病的保护性等位基因[J].2005,(5).
[4]王玉霞,吴志香,高淑兰,等.辽宁地区PPARγ2基因Pro12Ala多态性与2型糖尿病的相关性研究[J].2010,(7).
[5]李秀丽,朱本章,章琳,等.PPARγ2基因Pro12Ala多态性与2型糖尿病一级亲属的相关性[J].2006,(5).
[6]张弢,白然,刘加和,等.过氧化体增殖物激活型受体γ2基因多态性与2型糖尿病及其早期动脉粥样硬化的相关性[J].2005,(5).
[7]唐新,林婴,黄文芳,等.PPARG基因单核苷酸多态性与2型糖尿病血脂异常的相关性研究[J].2009,(3).
[8]董艳,李果,骆天红,等.PPARγ2基因Prol2Ala多态性与上海地区2型糖尿病的相关性[J].2004,(5).
[9]杨雪梅,李茵茵,林姗姗,等.PPARγ2基因Pro12Ala多态性与2型糖尿病及其大血管病变的相关性[J].2010,(1).
[10]周坚.过氧化物酶体增殖物激活受体基因多态性与Ⅱ型糖尿病患者的影响[J].2007,(7).
[11]翟冰,叶玲,刘建伟,等.北京社区人群脂联素和过氧化物酶增殖物活化受体γ2基因多态性及其交互作用与2型糖尿病的关系[J].2006,(4).
[12]于会艳,秦斌,龚涛,等.中国人群β-纤维蛋白原-455G/A基因多态与缺血性脑卒中发病风险的Meta分析[J].2006,(24).
[13]曹明芹,薛茜,韩英.统计推断中检验效能的估计及应用[J].2004,(5).
[14]胡文超,刘德敏,孙颖,等.PPARγ、TLR4基因多态性与2型糖尿病的相关性研究[J].2008,(3).
[15]傅茂,程桦,李秀钧,等.过氧化物酶增殖体激活受体-γ2基因Pro12Ala变异与2型糖尿病的关系[J].2002,(3).
[16]王丹,牟振云,翟俊霞,等.Stata软件在Meta-分析发表性偏倚识别中的探讨[J].2008,(15).
[17]牛丹,白玉杰,阎小君.PPAR-γ2基因Pro12Ala多态性与2型糖尿病的关联性[J].2004,(16).
[18]金梅花,金艳花,杨康鹃,等.延边地区朝鲜族和汉族PPAR-γ2基因Pro 12 Ala多态性与2型糖尿病关系的研究[J].2007,(1).
[19]Ying, Lin,Pengqiu, Li,Li, Cai,etc.Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.[J].2010,11.
[20]R, DerSimonian,N, Laird.Meta-analysis in clinical trials.[J].1986,7(3).
[21]刘风静,刘长山,冯波,等.中国潍坊地区汉族人过氧化体增殖物激活型受体γ2基因Prol2Ala多态性与糖尿病的相关性[J].2009,(2).
[22]R, Mukherjee,P J, Davies,D L, Crombie,etc.Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.[J].1997,386(6623).
[23]Tobe K,Ueki K,Umesono K,etc.Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.[J].1998,101(6).
[24]N, MANTEL,W, HAENSZEL.Statistical aspects of the analysis of data from retrospective studies of disease.[J].1959,22.
[25]J, Lau,J P, Ioannidis,C H, Schmid.Quantitative synthesis in systematic reviews.[J].1997,127(9).
[26]P, Tontonoz,E, Hu,B M, Spiegelman.Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.[J].1994,79.
[27]Nath SK,Lee YH,Harley JB.Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility.[J].2006,14(3).
[28]Hirschhorn JN.,Lander ES.,Daly M.,etc.The common PPAR gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes[J].2000,26(1).
[29]M, Koch,K, Rett,E, Maerker,etc.The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects.[J].1999,42.
[30]Egger M.,Smith G. D.,Schneider M.,etc.Bias in meta-analysis detected by a simple, graphical test[J].1997.
[31]谢春英,邓春艳,孙顺昌,等.PPARγ2基因PRO12ALA多态性与广东地区2型糖尿病的关系[J].2009,(2).
[32]Sandhu MS,Higgins JP,Harding AH,etc.The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.[J].2010,171(6).
[33]Iwamoto Y,Matsutani A,Ikegami H,etc.The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.[J].2001,50(4).
[34]Fajas L.,Nemoto M.,Pihlajamaki J.,etc.A Pro12Ala substitution in PPAR gamma 2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity[J].1998,20(3).
[35]Desvergne B,Wahli W.Peroxisome proliferator-activated receptors: nuclear control of metabolism.[J].1999,20(5).
[36]Yang W,Lu J,Weng J,etc.Prevalence of diabetes among men and women in China.[J].2010,362(12).
[37]Higgins JP,Thompson SG.Quantifying heterogeneity in a meta-analysis.[J].2002,21(11).