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Effects of pioglitazone on urinary transforming growth factor-β1 excretion in type 2 diabetics
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2011.06.007
- Key Word:
- 糖尿病性肾脏疾病;转化生长因子β1;吡格列酮
Abstract： 目的 观察吡格列酮对2型糖尿病(T2DM)患者尿转化生长因子β1(TGF-β1)排泄的影响,探讨其肾脏保护作用及机制.方法 98例血糖控制欠佳的T2DM患者随机分为联合吡格列酮(DP组)和磺酰脲类(DS组),治疗12周.检测治疗前后FPG、HbA1 c、尿白蛋白(UAlb)、肌酐(Cr)和TGF-β1水平.结果 (1)治疗后,两组患者FPC、HbA1c和尿TGF-β1/Cr比值均显著降低,差异均有统计学意义.DP组UAlb/Cr比值(UAER)显著降低(P＜0.01);DS组UAER轻度降低,差异无统计学意义.(2)治疗后两组间FPG和HbA1c比较,差异无统计学意义.与DS组治疗后比较,DP组治疗后UAER和TGF-β1/Cr值显著降低(P＜0.05).(3)尿TGF-β1/Cr值与UAER显著正相关(r=0.367,P＜0.01).结论吡格列酮可减少T2DM患者UAlb和TGF-β1排泄,其肾脏保护作用可能与其抑制体内TGF-β1表达和排泄有关.
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