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Comparison of diagnostic sensitivity and specificity for diabetic kidney disease among different assays of urinary protein
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2011.06.006
- Key Word:
- 糖尿病性肾脏疾病;糖尿病视网膜病变;尿白蛋白排泄率;尿白蛋白/肌酐比值
Abstract： 目的 比较尿蛋白的3种评价方法对于糖尿病性肾脏疾病(DKD)临床诊断的敏感性和特异性.方法 对349例2型糖尿病患者进行24小时尿总蛋白(UTP)、尿白蛋白排泄率(UAER)、尿白蛋白/肌酐比值(ACR)测定及眼底检查,行工作特征曲线(ROC)分析,并观察3种方法与视网膜病变(DR)的相关性.结果 ACR的ROC曲线下面积(AUC)是0.71,大于UAER的0.61和UTP的0.61(P＜0.01),ACR诊断DKD的敏感性是68.42%(男)、60.0%(女),特异性是71.7%(男)、73.73%(女),均高于UTP和UAER.ROC曲线得出的UAER最佳临界点是54.95μg/min.ACR-DR相关系数r为0.43,高于UTP-DR、UAER-DR的相关系数.结论 初步研究显示ACR对于DKD诊断的准确性高于UTP和UAER,且ACR的敏感性和特异性高.
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