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The effects of insulin detemir on blood glucose and body weight in obese and non-obese type 2 diabetic patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2011.06.004
- Key Word:
- 糖尿病,2型;肥胖;地特胰岛素
Abstract： 目的 观察地特胰岛素治疗24周对2型糖尿病(T2DM)肥胖及非肥胖患者血糖及体重的影响.方法 选取既往未接受过胰岛素治疗的T2DM患者54例,根据BMI分为肥胖(Ob)组24例和非肥胖(NOb)组30例,检测治疗前后体重、FBG、HbA1c,计算BMI、胰岛素用量等.结果 地特胰岛素治疗24周后,Ob组和NOb组FBG[(7.3±1.2)mmol/L、(6.7±1.5)mmol/L]、HbA1c[(7.3±0.9)%、(6.5±0.8)%]均较基线值{FBOE(9.4±2.5)mmol/L、(8.1±1.7)mmol/L]、HbA1c[(8.2±1.1)%、(7.6±1.9)%]}明显下降(P＜0.05);Ob组治疗前后BMI变化[(-1.51±1.10)kg/m2]与NOb组[(0.15±1.00)kg/m2]比较,差异有统计学意义(P＜0.05).结论 地特胰岛素治疗可有效降低肥胖和非肥胖T2DM患者血糖,且无明显体重增加效应.
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