Effect of the treatment with Shenling-composed prescription on insulin-like growth factor-1 in T2DM rats with insulin resistance
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1006-6187.2011.03.0012
- Key Word:
- 参苓组方;胰岛素样生长因子1;糖尿病,2型;胰岛素抵抗; Shenling-composed prescription;Insulin-like growth factor-1; Diabetes mellitus,type 2; Insulin resistance
Abstract： Objective To observe the effects of Shenling composed prescription （SLCP）on the metabolic pathway of insulin-like growth factor 1 (IGF-1) and the insulin resistance associated indexes in insulin resistant rats with type 2 diabetes mellitus. Methods T2DM rat model was created and assigned to different groups. Results Changes of fasting blood glucose, fasting insulin, total cholesterol, triglyceride, glycosylated hemoglobin HbA1c, insulin-like growth factor 1, insulin activity index, insulin resistance index were lower, IGF-1 concentration and IAI were higher in the Shenling-composed prescription group than in T2DM group. Conclusions Shenling-composed prescription has roles in improving insulin resistance and IGF-1 level in T2DM rats.
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