Abstract： Objective To explore effects of puerarin on the levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and high sensitive C-reactive protein (hsC-RP) and their clinical significance in DM patients with carotid atherosclerosis (CA). Methods 80 T2DM patients with CA were divided into puerarin group and control group. sICAM-1, sVCAM-1 and hsC-RP were determined by ELISA and compared between the two groups after treatment. Results The puerarin group had a lower levels of sICAM-1, sVCAM-1, hsC-RP and hemorrheologic parameters than control group (all P＜0.05) after treatment. Conclusions Puerarin can improve hemorrheology, regulate the cell adhesion molecules and control the inflamation, which has a protective role in diabetic vascular disease.