Single nucleotide polymorphism haplotypes of adiponectin gene are associated with type 2 diabetes in Han population
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-6187.2011.02.005
- Key Word:
- 糖尿病,2型;脂联素基因;单核苷酸多态性;单倍型;Diabetes mellitus, type 2;Adiponectin gene; Single nucleotide polymorphism; Haplotype
Abstract： Objective To investigate the association of single nucleotide polymorphism (SNP) haplotypes in adiponectin gene with type 2 diabetes mellitus (T2DM). Methods The study included 202 patients with T2DM and 143 nondiabetic(NDM) healthy subjects with no family history of diabetes. Using polymerase chain reaction-based restriction fragment-length polymorphism (PCR-RFLP), we genotyped the SNP-11391, SNP-11377, SNP-4522, SNP+45 and SNP+331 in adiponectin gene, and constructed their haplotypes. Then, we assessed the association of the five SNPs with T2DM. Results (1)The genotypic and allelic frequencies of SNP-11391, SNP-11377, SNP-4522, SNP+45 and SNP+331 had no significant difference between T2DM and NDM groups (all P>0.05). (2)The frequencies of haplotype SNP-11377C-SNP-4522T had difference between T2DM and NDM groups(P=0.02). Conclusions The haplotype SNP-11377C-SNP-4522T of adiponectin gene is associated with increased T2DM risk (Or=1.60, 95%CI:1.09~2.35).
- [1]刘合焜,陈素云,张思仲,等.脂联素基因单核苷酸多态性与Ⅱ型糖尿病合并肥胖及胰岛素抵抗相关联[J].2007,34(10).
- [2]魏颖丽,霍正浩,赵巍.我国西部人群脂联素基因+45位点多态性与肥胖、胰岛素抵抗及2型糖尿病的相关性[J].2007,(10).
- [3]刘德敏,靳立忠,于德民,等.2型糖尿病患者中脂联素基因多态性的研究[J].2004,(6).
- [4]王遂军,贾伟平,包玉倩,等.脂联素基因多态性与肥胖、血清脂联素水平的相关性[J].2008,(7).
- [5]王淑芳,赵家军,姜强,等.脂联素基因多态性与2型糖尿病相关性研究[J].2007,(1).
- [6]夏晖,莫永珍,卞茸文,等.中国人脂联素基因单核苷酸多态性与2型糖尿病的相关性[J].2004,(3).
- [7]李奕平,张瑛,李显丽,等.脂联素基因SNP-11377、SNP+45和SNP+276与代谢综合征的相关性[J].2009,(9).
- [8]史晓红,金锋,王沥,等.脂联素基因启动子区-11377C/G单核苷酸多态性与中国北方汉族人2型糖尿病的关系[J].2007,(34).
- [9]Eto Kazuhiro,Yasuda Kazuki,Tomita Motowo,etc.Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.[J].2002,51(2).
- [10]Scholmerich J,Schmitz G,Schaffler A,etc.Gly15Gly polymorphism within the human adipocyte-specific apM-1gene but not Tyr111His polymorphism is associated with higher levels of cholesterol and LDL-cholesterol in caucasian patients with type 2 diabetes.[J].2001,109(6).
- [11]Delannoy V,Boutin P,Bihain B,etc.Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.[J].2002,11(21).
- [12]Sinaiko AR,Steinberger J,Jacobs-DR Jr,etc.The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.[J].2009,125(1).
- [13]Adili Abulaiti,Claes-Goeran Oestenson,Suad Efendic,etc.Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians[J].2004,53(Suppl.1).