Relationship between the serum adiponectin and insulin resistance and its effect of rosiglitazone in metabolic syndrome patients without diabetes

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Author:
ZHENG Yu-yun()
WEN Hui-hua()
CHEN Li-zhu()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 18, Issue 11, 2010
DOI:
10.3969/j.issn.1006-6187.2010.11.003
Key Word:

Abstract: Objective To study a serum adiponectin level and a relationship between serum adiponectin and insulin resistance in metabolic syndrome (MS) patients without diabetes and to investigate its influence of rosiglitazone(RGZ). Methods Besides control group(n=30),92 MS patients without diabetes were divided randomly into A group(n=40,routine treatment ) and B group(n=52,plus RGZ). The serum adiponectin was measured by enzyme linked immunosorbent assay,HOMA-IR,and insulin sensitivity index(ISI) were calculated. Results The serum adiponectin was significantly lower in metabolic syndrome group than in normal control group[(1.15±0.81)mg/L vs (4.81±1.20 )mg/L, P<0.01].The serum adiponectin level was negatively correlated with HOMA-IR(P<0.01), and positively correlated with ISI(P<0.01). There was a significant increase in serum adiponectin [(2.52 ±1.37) mg/L vs (0.89±0.73)mg/L,P<0.01] and ISI(-4.61±0.45 vs -4.61±0.45,P<0.01), a significant decrease in HOMA-IR(0.99±0.35 vs 1.50±0.45,P<0.01)in B group versus A group. Conclusions The serum adiponectin in MS cases without diabetes is significantly decreased,negatively correlated with HOMA-IR. There is a significant increase in serum adiponectin and ISI, a significant decrease in HOMA-IR after RGZ treatment in MS cases without diabetes.  

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