Relationship of serum uric acid concentration with hypertension and metabolic syndrome in coastal areas population of Shandong province

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SUN Rui-xia()
MIAO Zhi-min()
LI Chang-gui()
Journal Title:
Volume 18, Issue 10, 2010
Key Word:

Abstract: Objective To study the relationship of serum uric acid (SUA) concentration with hypertension (HT) and metabolic syndrome (MS). Methods A total of 4114 adult subjects from coastal areas of Shandong province were divided into 4 groups according to SUA quartiles and gender. Mean values of variables between all quartiles were analyzed by covariance. The difference in the prevalence of HT and MS among all quartiles was analyzed by χ2 test. Correlation between SUA and metabolic or anthropometric variables was analyzed by partial correlation. The contribution of metabolic or anthropometric variables to HT and MS was determined by linear regression and binary regression. Results The SUA was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), body mass index (BMI), triglycerides (TG), total cholesterol (TC) and fasting plasma glucose (FPG), and negatively correlated with high density lipoprotein cholesterol (HDL-C) and gender. The prevalence of HT and MS gradually elevated along with SUA increasing (linear P<0.01). Odds ratios of HT and MS in the fourth quartile group vs the first quartile group were 1.72 (95%CI 1.31~2.27)and 4.59 (95%CI 3.09~6.81) for male, and 2.03 (95%CI 1.55~2.66) and 4.09 (95%CI 3.09~6.81) for female (P<0.01). SUA was independently correlated with each MS component (P<0.001). However, logistic analysis showed that hyperuricacidemia was not independently correlated with MS (P>0.05). Conclusions The prelavence of HT and MS is gradually elevated along with increasing SUA levels. SUA is closely correlated with MS component, but hyperuricacidemia is not an independent risk factor for MS.

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