Abstract： ObjectiveTo investigate the changes of plasma Chemerin level and the relationship between plasma Chemerin level and blood pressure, waist hip ratio (WHR), blood lipids, blood glucose, plasma insulin levels as well as other factors in newly diagnosed type 2 diabetic patients with hypertension.MethodsPlasma Chemerin levels were assayed by ELISA in the newly diagnosed type 2 diabetes mellitus (T2DM) , type 2 diabetic patients with hypertension (T2DM+HT) and normal controls (NC). The relationship between plasma Chemerin levels and blood pressure, BMI, WHR, blood lipids and HOMA-insulin resistance index (HOMA-IR ) as also analyzed.ResultsPlasma Chemerin level in T2DM+HT was significantly increased,as compared with T2DM and NC ［(74.6±6.4） vs （68.6±12.5 ）and （62.1±19.3)μg/L，both P<0.01］. Plasma Chemerin level correlated positively with age, body weight, waist circumference(WC), hip circumference, DBP,visceral fat%(FAT%), BMI, WHR, TG, FFA, FPG, 2hPG, FIns, 2hPIns, HOMA-IR, HbA1c（r=0.20, 0.25, 0.33, 0.20, 0.27, 0.30, 0.34, 0.24, 0.25, 0.16, 0.17, 0.21, 0.18, 0.21, 0.21, 0.19 ,respectively P<0.01 and P<0.05）.Multiple regression analysis showed that WC, DBP, 2hPINS, HbA1c were independent related factors influencing plasma Chemerin level.ConclusionsThe changes of Chemerin levels are associated with glucose and lipid metabolism and blood pressure, and it may contribute, in part, to the pathogenesis of IR and diabetes complicated with hypertension.