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The association between stromal cell derived factor-1α(SDF-1α) and diabetic nephropathy in T2DM
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2010.09.010
- Key Word:
- 糖尿病,2型;糖尿病肾病;SDF-1α;hsC-RP
Abstract： 目的 探讨糖尿病肾病患者血清中基质细胞趋化因子1α (SDF-1α)的水平, 与血糖、血脂、胰岛素抵抗、高敏C反应蛋白(hsC-RP)等的相关性. 方法 选取健康对照(NC)组31名, 2型糖尿病(T2DM)组151 例.检测hsC-RP、HbA1c、TG、TC等生化指标,ELISA法检测血清SDF-1α,计算HOMA-IR. 结果 T2DM组SDF-1α明显高于NC组(P<0.01).伴有肾病组高于不伴有肾病组,大量白蛋白尿组高于微量白蛋白尿组 ,但差异无统计学意义(P>0.05).SDF-1α与hsC-RP、HbA1c、HOMA-IR和尿白蛋白/肌酐(UAlb/Cr)呈正相关,与血脂不相关.T2DM组hsC-RP与HbA1c、HOMA-IR、UAlb/Cr呈正相关(P<0.01). 结论 T2DM患者SDF-1α水平升高,可能参与糖尿病肾病的炎症和免疫反应过程.
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