You Position: Home > Paper
Relationship of VEGF gene C(-634)G polymorphism and plasma level of VEGF with diabetic retinopathy
( views:487, downloads:225 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2010.06.011
- Key Word:
- 糖尿病视网膜病变;血管内皮生长因子;多态性,基因
Abstract： 目的 探讨血管内皮生长因子(VEGF)基因C(-634)G多态性及血浆中VEGF水平与糖尿病视网膜病变(DR)的关系. 方法 在昆明地区汉族人中检测96名正常对照者(NC组)和285例T2DM患者的VEGF基因C(-634)G多态性及血浆中VEGF水平. 结果 DR组CC基因型和C等位基因频率显著高于非DR(NDR)组(P均<0. 05),DR组中CC基因型者血浆VEGF水平高于CG及GG基因型者和NC组(P<0. 05或P<0. 01). 结论 VEGF基因C(-634)G多态性是昆明地区汉族T2DM患者发生DR的危险因素.
- [1]杨莹,张瑛,李晓进,等.Taqman探针检测VEGF基因多态性的实验研究[J].2008,(6).
- [2]Dunai G,Tulassay T,Hajdu J,etc.Association of genetic polymorphisms of vascular endothelial growth factor and risk for proliferative retinopathy of prematurity.[J].2005,57(3).
- [3]Funatsu H,Iwasaki N,Iwamoto Y,etc.Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy.[J].2009,247(1).
- [4]Funatsu H,Noma H,Mimura T,etc.Association of vitreous inflammatory factors with diabetic macular edema.[J].2009,116(1).
- [5]Ohkubo T,Katayama S,Watanabe M,etc.A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.[J].2002,51(5).