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The correlation of serum vaspin with insulin sensitivity and its related factors in different glucose tolerance individuals
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2010.06.008
- Key Word:
- Vaspin;糖尿病,2型;胰岛素抵抗
Abstract： 目的 研究不同糖耐量患者血清Vaspin水平变化与胰岛素敏感性等相关因素的关系. 方法 89例研究对象分为正常对照、糖耐量减低和2型糖尿病3组.检测人体测量参数和生化指标,留取血样测FPG、FIns、血脂、HbA1c、Vaspin水平,采用稳态模式评估胰岛素抵抗指数(HOMA-IR)等,分析这些参数在各组人群间的关系. 结果 (1)2型糖尿病组女性血清Vaspin水平显著高于男性(1.22±0.35 vs 1.01±0.27,P<0.05);(2)三组人群血清Vaspin水平无明显差异(1.13±0.47 vs 1.09±0.33 vs 1.11±0.33,P>0.05);(3)在对性别、年龄、身高、体重、BMI进行校正后,血清Vaspin与FIns成正相关(r=0.244,P<0.05)与LDL-C呈负相关(r=-0.266,P<0.05).FIns、HOMA-IR、BMI是影响血清Vaspin的独立相关因素. 结论 空腹血清Vaspin水平正相关于空腹胰岛素,负相关于LDL-C;FIns,HOMA-IR和BMI是影响血清Vaspin的独立相关因素.
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