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Analysis of the clinical characteristics and differential diagnosis in 186 cases with type 1 and type 2 diabetes in young adult and children
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2010.06.006
- Key Word:
- 糖尿病,1型;糖尿病,2型;青少年;诊断
Abstract： 目的 分析青少年1型和2型糖尿病发病的临床特点、鉴别诊断. 方法 回顾性分析北京协和医院内分泌科2000-2005年收治的111例1型糖尿病和75例2型糖尿病患者,年龄<30岁.分析各项临床和试验室指标的差异,OR和受试者工作特征曲线(ROC曲线). 结果 1型糖尿病易出现发病前感染(35.1%)、糖尿病酮症酸中毒(71.2%).2型糖尿病患者更易有肥胖史(95.7%)、脂肪肝(70.7%)和黑棘皮症(54.7%),BMI[(28.12±4.38)kg/m2]、空腹C肽(FC-P)[2.80(0.5～8.2)ng/ml]、HOMA2-IR[1.7(0.4～6.1)]较高(P<0.05).OR值最高的为黑棘皮症,无穷大(∞),其次为脂肪肝(78.6)、肥胖史(8.5).计算AUC,最高为BMI、 HOMA2-IR、FC-P,诊断2型糖尿病的最佳切点为BMI=23 kg/m2、HOMA2-IR=0.75、FC-P=1.0ng/ml.结论 在青少年中两种糖尿病最具鉴别的指标为黑棘皮症、脂肪肝、肥胖史及BMI,HOMA2-IR,FC-P.
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