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The observation of association of related loci on chromosome 2 with type 2 diabetes in the Shandong province population
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 5
- DOI:
- 10.3969/j.issn.1006-6187.2010.05.005
- Key Word:
- 糖尿病,2型;染色体;遗传;DNA混合池
Abstract： 目的 用DNA混合池与微卫星遗传标记寻找2型糖尿病的关联遗传位点,定位致病基因.方法在2号染色体上间隔10厘摩(cmol/L)遗传距离选择了30个微卫星遗传标记,分别对284例有家族史的2型糖尿病患者(T2DM组)和1000名正常对照者(NC组)各自组成的DNA混合样本进行扫描,比较T2DM组与NC组每个等位基因频率的差异.结果 在D2S286与D2S335位点T2DM组和NC组的等位基因频率存在统计学差异(P≤0.01).结论 山东省汉族人群家族史阳性的2型糖尿病患者群体在2号染色体D2S286和D2S335位点存在关联,为筛查易感基因提供了线索.
- [1]周鹏,魏然,温晓燕,等.山东半岛东部地区精神分裂症21号染色体基因扫描研究[J].2006,(4).
- [2]赵进英,王亘,熊墨淼,等.中国北方汉族2型糖尿病易感基因位点的定位[J].2000,(11).
- [3]魏然,周鹏,温晓燕,等.山东半岛东部地区精神分裂症8号染色体基因扫描研究[J].2007,(2).
- [4]孙彩霞,朱大龙,王亚平.全基因组筛查与2型糖尿病相关基因[J].2007,(5).
- [5]Lisa F. Barcellos,William Klitz,L. Leigh Field,etc.Association Mapping of Disease Loci, by Use of a Pooled DNA Genomic Screen[J].1997,61(3).
- [6]Bowden DW,Kent Taylor,Kimmel PL,etc.Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND).[J].2008,57(1).
- [7]Johnson MP,Griffiths LR.A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach.[J].2005,50(12).
- [8]Dina C,Froguel P,Hara K,etc.Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.[J].2002,51(4).
- [9]Tuomi T,Almgren P,Sjogren M,etc.A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.[J].2003,12(15).
- [10]Bowden DW,Meoni LA,Nicholas SB,etc.Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND).[J].2007,56(6).