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The effect of different course and class of hypertension on early insulin secretion of β-cell function
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 5
- DOI:
- 10.3969/j.issn.1006-6187.2010.05.002
- Key Word:
- 高血压;早期胰岛素分泌;胰岛素抵抗
Abstract： 目的 探讨高血压患者胰岛β细胞早期分泌功能变化与高血压病程和分级的关系.方法 确诊高血压患者106例,按病程与分级分为初诊组35例,5年内组34例,5年以上组37例;高血压1级组53例,2级组30例,3级组23例.治疗前行OGTT,测空腹和餐后30min血糖、胰岛素、C肽、尿素氮、肌酐及尿白蛋白等.计算HOMA-IR、早期胰岛素分泌指数(ΔI30/ΔG30)的变化.结果 (1)β细胞早期分泌时相在高血压5年以上组出现损害,分泌量较初诊组和5年内组分别减少43%和40%,在高血压各分级组无明显差异(P＞0.05).(2)随着高血压病程和分级增加,胰岛素抵抗及蛋白尿也逐渐加重.结论高血压病程5年以上,3级高血压均与β细胞早期分泌功能和肾损害相关.
- [1]牛文彦,王野虹,汤新之.高血压患者胰岛素受体基因突变的检测[J].1999,(1).
- [2]严励,何扬,薛声能,等.胰岛β细胞分泌功能评估指标的比较--186例不同糖耐量者葡萄糖耐量试验资料分析[J].2005,(6).
- [3]Weng J.Induction of Long-term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients Is Associated With Improvement of {beta}-Cell Function.[J].2004,27(11).
- [4]Gress TW,Nieto FJ,Shahar E,etc.Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study (see comments)[J].2000,342(13).