Association between circulating endothelial progenitor cell amount and macrovascular complication in patients with type 2 diabetes mellitus

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ZHANG Hui-feng()
ZHAO Zhi-gang()
YUAN Hui-juan()
Journal Title:
Volume 18, Issue 4, 2010
Key Word:

Abstract: Objective To investigate the correlation between the number and activity of circulating endothelial progenitor cells (EPCs) and macrovascular complication of patients with type 2 diabetes mellitus. Methods 89 T2DM subjects were divided into macrovascular complication group(MVC) and noncomplication group(NMVC),and 27 healthy subjects were controls. Circulating EPCs were counted via fluorescenceactivated cell sorter analysis. EPCs were also isolated from peripheral blood and cultured in vitro for 7 days, then identified. EPCs migration activities and proliferation activities were determined. ResultsCirculating EPCs number was significantly lower in MCV group than in NMCV group[(0.37±0.03)‰ vs (0.46±0.06)‰,P<0.01]and control group (P<0.05). HOMAIR index and HbA1c were negatively correlated with number of circulating EPCs and proliferation and migration capacities of EPCs and also significantly lower in MCV group than in NMCV group (all P<0.05) and control group (all P<0.05). ConclusionsInsulin resistence and highglucose are related to the occurrence and development of macrovascular complication of patients with T2DM possibly via reducing the number and activities of circulating EPCs.

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