You Position: Home > Paper

Association between circulating endothelial progenitor cell amount and macrovascular complication in patients with type 2 diabetes mellitus

( views:300, downloads:310 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
4
DOI:
10.3969/j.issn.1006-6187.2010.04.011
Key Word:
糖尿病,2型;大血管并发症;胰岛素抵抗;内皮祖细胞;Diabetes mellitus,type 2;Macrovascular complication;Insulin resistance;Endothelial progenitor cells

Abstract: Objective To investigate the correlation between the number and activity of circulating endothelial progenitor cells (EPCs) and macrovascular complication of patients with type 2 diabetes mellitus. Methods 89 T2DM subjects were divided into macrovascular complication group(MVC) and noncomplication group(NMVC),and 27 healthy subjects were controls. Circulating EPCs were counted via fluorescenceactivated cell sorter analysis. EPCs were also isolated from peripheral blood and cultured in vitro for 7 days, then identified. EPCs migration activities and proliferation activities were determined. ResultsCirculating EPCs number was significantly lower in MCV group than in NMCV group[(0.37±0.03)‰ vs (0.46±0.06)‰,P<0.01]and control group (P<0.05). HOMAIR index and HbA1c were negatively correlated with number of circulating EPCs and proliferation and migration capacities of EPCs and also significantly lower in MCV group than in NMCV group (all P<0.05) and control group (all P<0.05). ConclusionsInsulin resistence and highglucose are related to the occurrence and development of macrovascular complication of patients with T2DM possibly via reducing the number and activities of circulating EPCs.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn