Abstract： Objective To observe the relation of PON1 and PON2 polymorphisms with OxLDL level in T2DM. Methods The levels of OxLDL and PON1 and PON 2 polymorphism were detected in T2DM (n=210) and NC(n=105). Results Plasma OxLDL level in 210 patients with type 2 diabetes mellitus was higher than that in 105 healthy subjects(735.6±356.4 vs 421.1±163.2，P＜0. 01). The OxLDL level in the patients with QQ genotype of paraoxonase1 (PON1) was higher than in QR and RR genotypes (QQ＞QR＞RR:8122±3842 vs 7456±3412 vs 7154±3256,all P＜005).And OxLDL level in the patients with CC genotype of paraoxonase2(PON2) was also higher than in the other 2 genotypes (CC＞SC＞SS:796.5±1765 vs 7544±156.7 vs 731.6±142.4， P＜0.05).Multiple regression analysis showed that HbA1c，PON1 and PON2 were the independent predictors for plasma OxLDL level in type 2 diabetic mellitus. Conclusions PON1 and PON2 gene polymorphisms are genetic factors affecting plasma OxLDL level in type 2 diabetic mellitus.