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The effect of long-time insulin treatment on body weight and inflammatory factors in type 2 diabetic patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1006-6187.2010.03.007
- Key Word:
- 糖尿病,2型;胰岛素治疗;C反应蛋白;肿瘤坏死因子
Abstract： 目的 研究长期胰岛素治疗(疗程≥1年)对T2DM患者体重及炎症因子C-RP、TNF-α水平的影响.方法 胰岛素治疗疗程≥1年的T2DM患者60例,分析胰岛素治疗后的体重变化及其与C-RP、TNF-α、BMI、WHR的关系.结果 与体重无增加组相比,体重增加≥5kg组C-RP、TNF-α水平显著升高 (P＜0.01),BMI、WHR显著增加(P＜0.05);体重增加<5kg组C-RP、TNF-α、BMI水平无明显升高,WHR显著增加(P＜0.05).结论 2型糖尿病患者长期胰岛素治疗(疗程≥1年)所致的体重增加可能导致其C-RP、TNF-α水平及WHR明显升高.
- [1]Dytfeld J,Bogdanski P,Jablecka A,etc.Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus.[J].2007,45(10).
- [2].Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).[J].1998,352(9131).
- [3]Milne BJ,Poulton R,Williams SM,etc.Association between C-reactive protein, metabolic cardiovascular risk factors, obesity and oral contraceptive use in young adults.[J].2004,28(8).