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Association of Ghrelin gene Leu72Met polymorphism with type 2 diabetes mellitus in Dongxiang nationality
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1006-6187.2010.03.004
- Key Word:
- 糖尿病,2型;Ghrelin;基因多态性;变性高效液相色谱
Abstract： 目的 明确Ghrelin基因Leu72Met多态性在中国甘肃省东乡族的分布并探讨其与2型糖尿病的关系.方法 用PCR-DHPLC技术和测序法检测甘肃省东乡族T2DM患者及正常对照者(NC组)Ghrelin基因Leu72Met多态性.结果 Leu72Met基因型和等位基因频率在T2DM组和NC组中的分布差异无统计学意义(P＞0.05);NC组CA+AA型的FIns、HOMA-IR明显高于CC型;T2DM组CC基因型的FPG、血肌酐(SCr)水平明显高于CA+AA型(P均＜0.05).结论 Ghrelin基因Leu72Met多态性可能参与胰岛素抵抗和2型糖尿病的发病机制.
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