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Relationship between the level of serum amyloid A and insulin resistance in patients with combined type 2 diabetes and nonalcoholic fatty liver disease
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1006-6187.2010.03.003
- Key Word:
- 糖尿病,2型;脂肪肝,非酒精性;胰岛素抵抗;血清淀粉样蛋白A
Abstract： 目的 研究T2DM合并非酒精性脂肪肝(NAFLD)患者血清淀粉样蛋白A(SAA)水平与胰岛素抵抗(IR)的相关性.方法 测定T2DM合并NAFLD(DM+NAFLD)组32例、T2DM不合并NAFLD(DM)组34例、血糖正常的NAFLD(NAFLD)组31例及正常对照(NC)组32例SAA、肿瘤坏死因子(TNF-α)水平,计算HOMA-IR.结果 与NC组比,DM+NAFLD组、DM组及NAFLD组SAA、TNF-α水平均升高(P均<0.01);HOMA-IR(r=0.376,P<0.01)和TG(r=0.343,P<0.01)是SAA的独立影响因素.结论 SAA与IR关系密切,有可能在T2DM合并NAFLD的发生发展中起一定的作用.
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