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An analysis of association of UCP-2 A55V polymorphism with over-weight, obesity and type 2 diabetes in Dongxiang of Gansu people

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
2
DOI:
10.3969/j.issn.1006-6187.2010.02.011
Key Word:
解偶联蛋白;多态性,基因;糖尿病,2型

Abstract: 目的 探讨解偶联蛋白2(UCP-2)基因多态性与超重肥胖、2型糖尿病(T2DM)的关系.方法 选取甘肃东乡族人群正常对照(NC)114名及T2DM患者104例,采用聚合酶链反应和变性高效液相色谱技术筛查 UCP-2基因Ala55Val位点的基因型并测序. 结果 AA、AV、VV基因型频率和A、V等位基因频率NC组和T2DM组比较,差异无统计学意义;两组中VV型、AV型者TG水平均高于AA型者,NC组VV型者BMI明显高于AA型者,差异均有统计学意义(P均<0.05). 结论 UCP-2基因Ala55Val的多态性可能与甘肃东乡族人群的超重肥胖及血脂异常相关,而与T2DM、胰岛素抵抗关系不大.

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