You Position: Home > Paper
Effect of gastric bypass surgery on the glucose metabolism during 1 year follow-up in type 2 diabetes patients in China
( views:434, downloads:416 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-6187.2010.02.003
- Key Word:
- 胃旁路术;糖尿病,2型;糖代谢
Abstract： 目的 探讨2型糖尿病(T2DM)患者胃旁路术(GBP)后的糖代谢变化规律. 方法 2006年1月至2007年6月期间,我院普外科住院的129例T2DM患者,按HbA_1c分为:A组,HbA_1c 7%～7.9%;B组,HbA_1c8%～9%;C组,HbA_1c>9%.三组患者均实施GBP手术,术前和术后1、3、6、12个月检查OGTT、胰岛素释放试验、C-P释放试验、HbA_1c和BMI,计算胰岛素分泌指数,术后随访1年.结果 (1)与术前相比,术后各组BMI呈下降趋势,C组术后明显降低,差异有统计学意义(P<0.01);(2)与术前相比,术后FPG水平逐渐下降至术后12个月,差异有统计学意义(P<0.01);(3)术后各组FIns水平无统计学差异;(4)与术前相比,A组术后12个月FC-P水平明显升高(P=0.006);(5)与术前相比,术后HbA_1c逐渐下降,术后12个月差异有统计学意义(P均<0.01);(6)与术前相比,A组术后12个月△I_(30)明显改善(P<0.01). 结论 GBP后T2DM患者糖代谢明显改善.
- [1]高宏凯.胃转流手术治疗2型糖尿病[J].2008,(4).
- [2]Ballantyne GH,Wasielewski A,Saunders JK.The surgical treatment of type II diabetes mellitus: changes in HOMA Insulin resistance in the first year following laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB).[J].2009,19(9).
- [3]W J, Pories,M S, Swanson,K G, MacDonald,etc.Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.[J].1995,222.
- [4]张新国,杨学军,徐红,等.手术治疗2型糖尿病-回顾性临床研究及近期临床试用报告[J].2005,004 (5).
- [5]Philip Schauer,Bartolome Burguera,Sayeed Ikramuddin,etc.Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus[J].2003,238(4).
- [6]Manco M,Guidone C,Castagneto M,etc.Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery.[J].2006,55(7).
- [7]Mingrone G.Role of the incretin system in the remission of type 2 diabetes following bariatric surgery.[J].2008,18(8).