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The effect of rosiglitazone on the expression of HGF in the survival pancreatic islet of diabetic rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2010.01.018
- Key Word:
- 罗格列酮;糖尿病;β细胞量;肝细胞生长因子
Abstract： 目的 观察罗格列酮对实验性1型糖尿病大鼠残存胰岛表达肝细胞生长因子(HGF)的影响. 方法 SD大鼠随机分为3组,正常对照(Con)组24只,糖尿病(DM)组24只,罗格列酮干预(RGZ)组24只.于应用罗格列酮后5个时间段分别测定各组FBG、FIns.免疫组化法检测胰岛中Ins及HGF的表达,并进行形态学量化分析. 结果 与DM组相比,RGZ组经罗格列酮干预后2周,血清胰岛素水平逐渐上升;血糖水平逐渐下降;胰腺相对β细胞量明显增多;胰岛HGF表达水平提高(P均<0.05).RGZ组胰岛HGF表达水平与胰腺相对β细胞量(r=0.766,P<0.05)及血清胰岛素水平(r=0.740,P<0.05)呈正相关. 结论 罗格列酮能增加实验性1型糖尿病SD大鼠β细胞数量,其机制可能与上调胰岛HGF的表达有关.
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